Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization

Reza Talaie, Pooya Torkian, Alexander Clayton, Stephanie Wallace, Hoiwan Cheung, Majid Chalian, Jafar Golzarian

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Osteoarthritis (OA) is the major cause of disability, affecting over 30 million US adults. Continued research into the role of neovascularization and inflammation related to osteoarthritis in large-animal models and human clinical trials is paramount. Recent literature on the pathogenetic model of OA has refocused on low-level inflammation, resulting in joint remodeling. As a result, this has redirected osteoarthritis research toward limiting or treating joint changes associated with persistent synovitis. The overall goal of this review is to better understand the cellular and tissue-specific mechanisms of inflammation in relation to a novel OA treatment modality, Genicular Artery Embolization (GAE). This article also assesses the utility and mechanism of periarticular neovascular embolization for the treatment of OA with a particular emphasis on the balance between pro-angiogenic and anti-angiogenic cytokines, inflammatory biomarkers, and imaging changes.

Original languageEnglish (US)
Article number1403
JournalDiagnostics
Volume12
Issue number6
DOIs
StatePublished - Jun 2022

Bibliographical note

Funding Information:
Funding: This study was not supported by any funding.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • embolization
  • genicular artery embolization
  • osteoarthritis

PubMed: MeSH publication types

  • Journal Article
  • Review

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