Emerging role of extracellular vesicles in prostate cancer

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Prostate cancer (PCa) is the second most common cancer among men in the United States. While the use of prostate-specific antigen has improved the ability to screen and ultimately diagnose PCa, there still remain false positives due to noncancerous conditions in the prostate gland itself and other prognostic biomarkers for PCa are needed. Contents within extracellular vesicles (EVs) have emerged as promising biomarkers that can give valuable information about disease state, and have the additional benefit of being acquired through noninvasive liquid biopsies. Meaningful communication between cancer cells and the microenvironment are carried by EVs, which impact important cellular processes in prostate cancer such as metastasis, immune regulation, and drug resistance.

Original languageEnglish (US)
Article numberbqab139
JournalEndocrinology (United States)
Issue number9
StatePublished - Sep 2021

Bibliographical note

Funding Information:
M.L. is supported by the Targets of Cancer Training Program grant T32 CA009138. J.M.D. is supported by the Department of Defense Prostate Cancer Research Program W81XWH-18-1-0542.

Publisher Copyright:
© The Author(s) 2021.


  • Biomarkers
  • Exosomes
  • Extracellular vesicles
  • Prostate cancer


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