Emerging issues in hepatitis C virus-positive liver and kidney transplant recipients

R. D. Bloom, J. R. Lake

Research output: Contribution to journalShort surveypeer-review

54 Scopus citations


Hepatitis C virus (HCV) infection is a major health care issue in liver and kidney transplantation. Besides negatively affecting both patient and graft survival, HCV is associated with a heightened risk for new onset diabetes mellitus (NODM). The mechanisms underlying the diabetogenicity of HCV are complex but are likely to involve insulin resistance caused by inhibitory actions of the virus on insulin regulatory pathways in the liver. The resultant glucose dysregulation is an important determinant of increased morbidity and mortality in liver and kidney recipients. This review highlights the concerns for outcomes in HCV-positive liver and kidney transplant patients with particular focus on the interrelationship between hepatitis C and diabetes. Data about the potential role of calcineurin inhibitors, corticosteroids and mycophenolate mofetil in HCV infection and HCV-associated NODM will also be discussed.

Original languageEnglish (US)
Pages (from-to)2232-2237
Number of pages6
JournalAmerican Journal of Transplantation
Issue number10
StatePublished - Oct 2006


  • Diabetes
  • Hepatitis C virus
  • Kidney transplantation
  • Liver transplantation


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