Emergence of resistance to chloramphenicol in Salmonella.

C. E. Cherubin, H. C. Neu, J. J. Rahal, L. D. Sabath

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Surveillance of antibiotic resistance of Salmonella isolates from humans in the north-eastern United States has detected resistance to chloramphenicol on 8 occasions, three of which were hospital outbreaks. Resistance was developed during treatment in 5 instances, and in another instance this situation was suspected. On 2 other occasions chloramphenicol-resistant Salmonella appear to have been imported from outside the country. Common features of the cases were multiple antibiotic resistance, transfer of R-factor, simultaneous presence of different patterns of resistance, similar patterns of antibiotic resistance in other intestinal bacteria, and apparent in vivo and in vitro loss of resistance to chloramphenicol with time.
Original languageUndefined/Unknown
Pages (from-to)807-812
Number of pages6
JournalJournal of Infectious Diseases
Issue number5
StatePublished - 1977


  • antibiotic resistance
  • drug resistance
  • geographic distribution
  • hospital infection
  • microorganism
  • R factor
  • Salmonella
  • salmonella albany
  • salmonella goettingen
  • salmonella typhimurium
  • theoretical study
  • ampicillin
  • carbenicillin
  • cefalotin
  • chloramphenicol
  • cotrimoxazole
  • gentamicin
  • kanamycin
  • streptomycin
  • sulfafurazole
  • tetracycline

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