Emergence of fecal microbiota transplantation as an approach to repair disrupted microbial gut ecology

Alexander Khoruts, Alexa R. Weingarden

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

In the recent years fecal microbiota transplantation (FMT) has emerged as an effective therapeutic option for patients with refractory Clostridium difficile infection that is not responding to antibiotic therapy. It results in implantation of donor microbiota into recipients and restoration of normal distal gut microbial community structure. We anticipate that this form of therapy represents merely the first entry into a new class of therapeutics. There is great interest in application of FMT or defined microbial consortia to treatment of many diseases associated with dysbiosis. However, many challenges remain in development as our understanding of microbial ecology within the human body and microbiota-host interactions remain limited. Future advances in this field will be critically depending on detailed mechanistic understanding.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalImmunology Letters
Volume162
Issue number2
DOIs
StatePublished - Dec 1 2014

Keywords

  • Clostridium difficile infection
  • Fecal microbiota transplantation

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