Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency

Samuel C. Blackman, Nell S. Lurain, David P. Witte, Alexandra H. Filipovich, Pam Groen, Mark R. Schleiss

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The authors describe a patient with autosomal-recessive severe combined immunodeficiency (SCID) with severe, multiorgan cytomegalovirus (CMV) disease. In the face of appropriate therapy, the patient developed a 100-fold gradient in viral load across the blood-brain barrier. Disseminated disease, including pneumonitis, contributed to a fatal outcome. Serial genotypic analyses revealed multiple UL97 and UL54 (DNA polymerase) mutations that conferred phenotypic resistance to all currently licensed systemic CMV antivirals.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalJournal of pediatric hematology/oncology
Volume26
Issue number9
DOIs
StatePublished - Sep 2004

Keywords

  • Antiviral resistance
  • Antiviral therapy
  • Cytomegalovirus
  • Severe combined immunodeficiency
  • UL97

Fingerprint Dive into the research topics of 'Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency'. Together they form a unique fingerprint.

Cite this