Embracing the heterogeneity of natural viruses in mouse studies

Jessica K. Fiege, Ryan A. Langlois

Research output: Contribution to journalReview articlepeer-review

Abstract

Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.

Original languageEnglish (US)
Article number001758
JournalJournal of General Virology
Volume103
Issue number6
DOIs
StatePublished - 2022

Bibliographical note

Funding Information:
RAL is supported by the McKnight Presidential Fellowship, the Academic Investment Research program from the University of Minnesota Medical School and NIH grant R01 AI50600.

Publisher Copyright:
© 2022 Microbiology Society. All rights reserved.

Keywords

  • dirty mice
  • microbiome
  • virome

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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