Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.
Bibliographical noteFunding Information:
RAL is supported by the McKnight Presidential Fellowship, the Academic Investment Research program from the University of Minnesota Medical School and NIH grant R01 AI50600.
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- dirty mice
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural