Embracing the heterogeneity of natural viruses in mouse studies

Jessica K. Fiege; Ryan A. Langlois

doi:10.1099/jgv.0.001758

Embracing the heterogeneity of natural viruses in mouse studies

Jessica K. Fiege, Ryan A. Langlois

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.

Original language	English (US)
Article number	001758
Journal	Journal of General Virology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1099/jgv.0.001758
State	Published - 2022

Bibliographical note

Funding Information:
RAL is supported by the McKnight Presidential Fellowship, the Academic Investment Research program from the University of Minnesota Medical School and NIH grant R01 AI50600.

Publisher Copyright:
© 2022 Microbiology Society. All rights reserved.

Keywords

dirty mice
microbiome
virome

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10.1099/jgv.0.001758

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Embracing the heterogeneity of natural viruses in mouse studies

Abstract

Bibliographical note

Keywords

Publisher link

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