Elucidating the Role of Apolipoprotein E Isoforms in Spinal Cord Injury-Associated Neuropathology

Carlos A. Toro; Dibash K. Das; Dongming Cai; Christopher P. Cardozo

doi:10.1089/neu.2018.6334

Elucidating the Role of Apolipoprotein E Isoforms in Spinal Cord Injury-Associated Neuropathology

Carlos A. Toro, Dibash K. Das, Dongming Cai, Christopher P. Cardozo

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Spinal cord injury (SCI) is a devastating, life-altering, neurological event that affects ∼300,000 individuals in the United States. Currently, there are no effective treatments to reverse the neurological impairments caused by the lesion. Until a cure is available, there is an urgent need for strategies that can either spare injured neurons or promote neuroplasticity and functional recovery. Genetic links to outcomes after SCI may provide insights into the pathological mechanisms, and possible new avenues for drug development. In the present review, we discuss the current knowledge linking apolipoprotein E genotypes with better or worse functional outcomes after an SCI, and the possible molecular mechanisms that may contribute to this association.

Original language	English (US)
Pages (from-to)	3317-3322
Number of pages	6
Journal	Journal of neurotrauma
Volume	36
Issue number	24
DOIs	https://doi.org/10.1089/neu.2018.6334
State	Published - Dec 15 2019
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the New York State Department of Health, Wadsworth Center, Innovative, Developmental or Exploratory Activities (IDEA) in Spinal Cord (NYS Spinal Cord Injury Research Board [SCIRB] Grant# DOH01-PART2-2017-00035 to C.P.C. and D.C.), and the Department of Veterans Affairs Rehabilitation and Development Service Grant B-2020-C.

Publisher Copyright:
© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019.

Keywords

SCI neuropathology
apolipoprotein E
functional recovery after SCI

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10.1089/neu.2018.6334

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abstract = "Spinal cord injury (SCI) is a devastating, life-altering, neurological event that affects ∼300,000 individuals in the United States. Currently, there are no effective treatments to reverse the neurological impairments caused by the lesion. Until a cure is available, there is an urgent need for strategies that can either spare injured neurons or promote neuroplasticity and functional recovery. Genetic links to outcomes after SCI may provide insights into the pathological mechanisms, and possible new avenues for drug development. In the present review, we discuss the current knowledge linking apolipoprotein E genotypes with better or worse functional outcomes after an SCI, and the possible molecular mechanisms that may contribute to this association.",

keywords = "SCI neuropathology, apolipoprotein E, functional recovery after SCI",

author = "Toro, {Carlos A.} and Das, {Dibash K.} and Dongming Cai and Cardozo, {Christopher P.}",

note = "Funding Information: This work was supported by the New York State Department of Health, Wadsworth Center, Innovative, Developmental or Exploratory Activities (IDEA) in Spinal Cord (NYS Spinal Cord Injury Research Board [SCIRB] Grant# DOH01-PART2-2017-00035 to C.P.C. and D.C.), and the Department of Veterans Affairs Rehabilitation and Development Service Grant B-2020-C. Publisher Copyright: {\textcopyright} Copyright 2019, Mary Ann Liebert, Inc., publishers 2019.",

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doi = "10.1089/neu.2018.6334",

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AU - Toro, Carlos A.

AU - Das, Dibash K.

AU - Cai, Dongming

AU - Cardozo, Christopher P.

N1 - Funding Information: This work was supported by the New York State Department of Health, Wadsworth Center, Innovative, Developmental or Exploratory Activities (IDEA) in Spinal Cord (NYS Spinal Cord Injury Research Board [SCIRB] Grant# DOH01-PART2-2017-00035 to C.P.C. and D.C.), and the Department of Veterans Affairs Rehabilitation and Development Service Grant B-2020-C. Publisher Copyright: © Copyright 2019, Mary Ann Liebert, Inc., publishers 2019.

PY - 2019/12/15

Y1 - 2019/12/15

N2 - Spinal cord injury (SCI) is a devastating, life-altering, neurological event that affects ∼300,000 individuals in the United States. Currently, there are no effective treatments to reverse the neurological impairments caused by the lesion. Until a cure is available, there is an urgent need for strategies that can either spare injured neurons or promote neuroplasticity and functional recovery. Genetic links to outcomes after SCI may provide insights into the pathological mechanisms, and possible new avenues for drug development. In the present review, we discuss the current knowledge linking apolipoprotein E genotypes with better or worse functional outcomes after an SCI, and the possible molecular mechanisms that may contribute to this association.

AB - Spinal cord injury (SCI) is a devastating, life-altering, neurological event that affects ∼300,000 individuals in the United States. Currently, there are no effective treatments to reverse the neurological impairments caused by the lesion. Until a cure is available, there is an urgent need for strategies that can either spare injured neurons or promote neuroplasticity and functional recovery. Genetic links to outcomes after SCI may provide insights into the pathological mechanisms, and possible new avenues for drug development. In the present review, we discuss the current knowledge linking apolipoprotein E genotypes with better or worse functional outcomes after an SCI, and the possible molecular mechanisms that may contribute to this association.

KW - SCI neuropathology

KW - apolipoprotein E

KW - functional recovery after SCI

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M3 - Review article

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JF - Journal of neurotrauma

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Elucidating the Role of Apolipoprotein E Isoforms in Spinal Cord Injury-Associated Neuropathology

Abstract

Bibliographical note

Keywords

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