Elucidating dynamic brain interactions with across-subjects correlational analyses of positron emission tomographic data: The functional connectivity of the amygdala and orbitofrontal cortex during olfactory tasks

David H. Zald, Michael J. Donndelinger, José V. Pardo

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Covariance analyses of positron emission tomography (PET) data are used increasingly to elucidate the functional connectivity between brain regions during different cognitive tasks. Functional connectivity may be estimated by examining the covariance between regions over time or across subjects. In functional brain-mapping studies, across-subjects covariance matrices derived from within-task (nonsubtracted) and between-task (subtracted) data characterize different, complementary aspects of functional interactions. The authors study amygdala-orbitofrontal interactions during three task conditions (aversive olfaction, odor detection, and resting with eyes closed) to illustrate the strengths and limitations of across-subjects covariance analyses based on subtracted and nonsubtracted data. This example underscores the dynamic nature of connectivity between the amygdalae and orbitofrontal cortices and highlights the importance of including data from resting conditions in covariance analyses.

Original languageEnglish (US)
Pages (from-to)896-905
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume18
Issue number8
DOIs
StatePublished - Aug 1998

Keywords

  • Brain blood flow
  • Brain mapping
  • Emotion
  • Neural modeling
  • Olfaction
  • Positron emission tomography

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