Elimination of quinolone antibiotic carryover through use of antibiotic- removal beads

R. A. Zabinski, A. J. Larsson, K. J. Walker, S. S. Gilliland, John C Rotschafer

Research output: Contribution to journalComment/debate

25 Scopus citations

Abstract

To prove the utility of antibiotic-removal beads in separating antibiotics from bacterial samples, Escherichia coli ATCC 25922 was exposed to five separate quinolones before and after each was exposed to antibiotic-removal beads. Plates treated with antibiotic solutions that were exposed to beads demonstrated antibiotic removal, and plates treated with antibiotic solutions that were not exposed to beads demonstrated antibiotic carryover. After exposure to beads, fluoroquinolone concentrations decreased from 5 μg/ml to 0.14 μg/ml (ciprofloxacin), 0.04 μg/ml (temafloxacin), <0.01 μg/ml (ofloxacin), <0.01 μg/ml (sparfloxacin), and 0.02 μg/ml (clinafloxacin). These data indicate that antibiotic carryover can be successfully circumvented through the use of antibiotic-removal beads.

Original languageEnglish (US)
Pages (from-to)1377-1379
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number6
DOIs
StatePublished - Jan 1 1993

Fingerprint Dive into the research topics of 'Elimination of quinolone antibiotic carryover through use of antibiotic- removal beads'. Together they form a unique fingerprint.

  • Cite this