Elevated serum angiotensin-converting enzyme (SACE) activity in acute pulmonary histoplasmosis

S. F. Davies, M. S. Rohrbach, V. Thelen, J. Kuritsky, R. Gruninger, M. L. Simpson, R. A. DeRemee

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9 Scopus citations


Serum angiotensin-converting enzyme (SACE) levels were measured in 44 subjects six weeks after acute pulmonary histoplasmosis. All patients were infected in a common-source outbreak of histoplasmosis which occurred on one day. All patients had both strictly defined clinical and serologic evidence of infection. The SACE activity was elevated at six weeks compared to normal controls, and seven of the 44 had levels more than 2 SD above the normal mean. SACE levels were also measured at three and 24 weeks after acute infection in a smaller number of the same subjects. Serial observations demonstrated that all subjects (including those with normal and elevated SACE at six weeks) had a rise and fall in SACE activity following symptomatic acute pulmonary histoplasmosis. Our findings suggest that elevated SACE does not reliably separate sarcoidosis from histoplasmosis, although elevations in histoplasmosis are much less common and may occur only briefly following acute pulmonary histoplasmosis. More important, it seems that SACE activity rises acutely in all patients with symptomatic acute histoplasmosis and then falls gradually toward baseline over several months, coinciding temporally with the granulomatous response.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
Issue number3
StatePublished - 1984

Bibliographical note

Funding Information:
Supported in part by grant HL-28482 from the National Heart, Lung, and Blood Institute, National Institutes of Health.


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