We hypothesized that malignant transformation of normal mucosa of the upper aerodigestive tract to squamous cell carcinoma of the head and neck (SCCHN) might be associated with altered CK2 activity in the chromatin compartment of these tumors. We measured CK2 activity in the cytosol and chromatin of 7 surgical specimens of SCCHN, and 5 specimens of normal oropharyngeal mucosa from non-smokers/non-drinkers. CK2 activity in SCCHN tumors was significantly elevated in both the nuclear chromatin (P < 0.0005) and cytosolic (P < 0.04) compartments relative to normal mucosa. These data suggest that activation or dysregulation of the chromatin-associated CK2 signal may play a role in the pathobiology of SCCHN.
Bibliographical noteFunding Information:
This work was supported in part by the American Academy of Otolaryngology, Head and Neck Surgery Research Training Award, the American Society for Head and Neck Surgery, the Medical Research Fund of the United States Department of Veterans Affairs, and NC1 Research Grant, CA-15062. A portion of this study was presented in abstract form at the Special Conference of the American Association for Cancer Research: Signal Transduction of Normal and Tumor Cells, Banff, Alberta, April, 1995.
- Head and neck tumors
- Protein kinase CK2 activity