Elevated platelet count, C-reactive protein and thromboxane analog-induced platelet aggregation in patients with Gulf War veterans' illnesses: Evidence of a chronic inflammatory state?

Gerhard J. Johnson, Linda A. Leis, Billie C.S. Slater, Ronald R. Bach

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A previous study of Gulf War veteran's illnesses (GWVI) observed evidence of platelet activation in a majority of patients with GWVI. To further characterize platelet function, we studied 43 patients (40 men) with GWVI (GWVI+) and 21 veterans who served concurrently in the Gulf War but who lacked criteria for GWVI (GWVI-). All participants were free of infection and known inflammatory diseases. Studies performed included platelet count, immature platelet fraction (IPF), plasma thrombopoietin (TPO), C-reactive protein (CRP), platelet aggregation and ATP secretion in response to six agonists, and spontaneous aggregation. Platelet counts and CRP were significantly elevated in GWVI+ compared to GWVI- patients without elevation in IPF or TPO. Platelet aggregation did not differ between GWVI+ and GWVI- patients except for spontaneous aggregation that was significantly greater in GWVI+ patients. Platelet ATP secretion was similar in the two groups, except the response to 50μmol/l thrombin receptor agonist peptide 6 (TRAP 6) was significantly greater in GWVI+ patients. When platelet aggregation was analyzed in relation to CRP, the response to 0.5μmol/l U46619 was significantly greater in patients whose CRP was at least 2μg/ml. Therefore, GWVI+ patients had elevated platelet counts, spontaneous aggregation, TRAP 6-induced secretion, and CRP, but no impairment of platelet function. The increased platelet counts and U46619-induced aggregation appear to be consequences of an underlying inflammatory state in GWVI.

Original languageEnglish (US)
Pages (from-to)736-741
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume24
Issue number7
DOIs
StatePublished - Oct 2013

Keywords

  • C-reactive protein
  • Gulf War illness
  • platelet aggregation
  • platelet secretion
  • thromboxane A

Fingerprint

Dive into the research topics of 'Elevated platelet count, C-reactive protein and thromboxane analog-induced platelet aggregation in patients with Gulf War veterans' illnesses: Evidence of a chronic inflammatory state?'. Together they form a unique fingerprint.

Cite this