Elevated Heparin-Precipitable Fraction of Plasma in Granuloma Annulare

The levels of heparin-precipitable fraction of plasma were determined in 17 patients with granuloma annulare and 26 persons used as controls. The mean level in patients was greater than the mean level in persons used as controls (P <.05). Patients with widespread, disseminated lesions tended to have higher levels than patients with more localized disease (P <.15). New lesions were actively forming in two patients with widespread disease at the time of study, and levels of heparin-precipitable fraction in these patients were among the highest found. The significance of these findings and their relationship to the etiopathogenesis of granuloma annulare is speculative.