Elevated granulocyte colony-stimulating factor, non-infectious leukocytosis and fevers in a patient with multiple myeloma

Meghan M. Sebasky, Pankaj Gupta, Gregory A. Filice

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: We report the case of a 56-year-old male with multiple myeloma in whom recurrent fevers and leukocytosis delayed potentially effective chemotherapy due to concern for active infection. Design and measurements: A thorough infectious workup, including CT and PET scans, was negative. The patient was eventually found to have an elevated serum granulocyte colony-stimulating factor (G-CSF) of 113 pg/ml (normal range 0.0 - 39.1 pg/ml), which was likely the cause of his persistent leukocytosis and fevers. Multiagent chemotherapy was initiated, and the fevers resolved in the next 4 days. Results: Leukocyte concentrations trended down after initiation of chemotherapy, but it is uncertain how much of the decline was attributable to immunosuppression. Conclusion: We report this well-documented case to demonstrate that G-CSF production should be considered as a cause of unexplained fever and leukocytosis in patients with multiple myeloma to prevent inappropriate and delayed definitive diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)2134-2135
Number of pages2
JournalJournal of general internal medicine
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2008

Keywords

  • Fever
  • Granulocyte colony-stimulating factor
  • Leukocytosis
  • Multiple myeloma

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