Electrostatic deformation of DNA by a DNA-binding protein

J. B. Matthew, D. H. Ohlendorf

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Complementary electrostatic interactions between negatively charged B-DNA and a positively charged array on the λ Cro repressor protein are shown to substantially contribute to the formation energy of sequence-specific and nonspecific Cro-DNA complexes. The electrostatic interactions favor Cro binding to a bent form of DNA, a geometry which optimizes hydrogen-bonding contacts between Cro and exposed base pair groups in the DNA major groove.

Original languageEnglish (US)
Pages (from-to)5860-5862
Number of pages3
JournalJournal of Biological Chemistry
Issue number10
StatePublished - 1985


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