Electrophysiological analysis of taurine and glycine action on neurons of the mudpuppy retina. II. ERG, PNR and Müller cell recordings

Robert A. Cunningham, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Extracellular electrophysiological recordings of the electroretinogram (ERG) and proximal negative response (PNR) were carried out in the perfused retina-eyecup preparation of the mudpuppy. Intracellular recordings were obtained from Müller cells. Bath-applied taurine/glycine had identical effects on the ERG, PNR and Müller cell responses and the effects of both agents were blocked by strychnine. Taurine and glycine suppressed the d-wave of the ERG, the OFF response of Müller cells and ON and OFF responses of the PNR. These observations show that taurine/glycine sensitivity is predominantly found in the OFF channel of the ERG whose underlying neuronal basis appears to be dark evoked depolarization of OFF bipolars.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalBrain Research
Volume197
Issue number1
DOIs
StatePublished - Sep 15 1980

Keywords

  • ERG
  • Müller cell
  • ON and OFF response
  • PNR
  • Retina
  • glycine
  • taurine

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