Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy

Hyunjin Kim, Young Min Lim, Joo Yea Jin, Dok Hyun Yoon, Cheolwon Suh, Sun Young Kim, Jae Cheol Jo, Kwang Kuk Kim

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8 Scopus citations


Introduction: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome and monoclonal gammopathy of undetermined significance (MGUS) are paraproteinemic disorders that can cause demyelinating polyneuropathy. Herein we assessed the findings of nerve conduction studies (NCS) in patients with POEMS syndrome and MGUS-related neuropathy to determine whether the NCS characteristics can help differentiate between these conditions. Methods: We enrolled 24 POEMS and 37 MGUS-related neuropathy patients. NCS parameters, including compound muscle action potential (CMAP), motor conduction velocity (MCV), and terminal latency index (TLI), were evaluated. Results: Compared with MGUS-related neuropathy patients, POEMS syndrome patients demonstrated a greater reduction in both the upper and lower limb CMAPs and a greater reduction in the median and ulnar MCVs. The TLIs were significantly higher in POEMS patients. Discussion: NCS can help distinguish POEMS syndrome from MGUS-related neuropathy. Reduced CMAPs, slow MCVs, and high TLIs are indicative of POEMS syndrome rather than MGUS-related neuropathy. Muscle Nerve 56: E73–E77, 2017.

Original languageEnglish (US)
Pages (from-to)E73-E77
JournalMuscle and Nerve
Issue number6
StatePublished - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.


  • MGUS-related neuropathy
  • POEMS syndrome
  • axonal loss
  • demyelination
  • nerve conduction study


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