Electrophysiologic and electrocardiographic characteristics and radiofrequency catheter ablation of focal atrial tachycardia originating from the left atrial appendage

Takumi Yamada, Yoshimasa Murakami, Yukihiko Yoshida, Taro Okada, Naoki Yoshida, Junji Toyama, Naoya Tsuboi, Yasuya Inden, Makoto Hirai, Toyoaki Murohara, Hugh T. McElderry, Andrew E. Epstein, Vance J. Plumb, G. Neal Kay

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Background: The left atrial appendage (LAA) is one of the major sources of focal atrial tachycardias (ATs). Objective: The purpose of this study was to investigate the detailed electrophysiologic characteristics and catheter ablation of focal ATs originating from the LAA. Methods: The study population consisted of 47 consecutive patients with 50 focal ATs originating from the left atrium (LA): LAA in 13, left pulmonary veins (PVs) in 14, right PVs in 12, and mitral annulus in 11. Programmed electrical stimulation and pharmacologic testing were performed to examine the mechanism of LAA AT. Left atriography was performed prior to radiofrequency ablation to identify the focus in the LAA. Results: The mechanism of LAA AT was automaticity in 11 and triggered activity in 2. The 13 LAA foci were located mainly at the LAA base: 11 on the medial side and 2 on the lateral side. Atrial activation sequences within the distal coronary sinus were helpful in differentiating these LAA foci. The criterion of a negative P wave in leads I and aVL indicating an LAA AT focus was associated with sensitivity of 92.3%, specificity 97.3%, positive predictive value 92.3%, and negative predictive value 97.3%. No complications occurred in any of the 13 patients. All 13 patients were free of atrial arrhythmias without any antiarrhythmic drugs during follow-up of 8 ± 3 years. Conclusion: LAA ATs have typical electrophysiologic and electrocardiographic characteristics that are helpful in guiding radiofrequency catheter ablation.

Original languageEnglish (US)
Pages (from-to)1284-1291
Number of pages8
JournalHeart Rhythm
Volume4
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Atrial tachycardia
  • Automaticity
  • Left atrial appendage
  • Radiofrequency catheter ablation
  • Triggered activity

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    Yamada, T., Murakami, Y., Yoshida, Y., Okada, T., Yoshida, N., Toyama, J., Tsuboi, N., Inden, Y., Hirai, M., Murohara, T., McElderry, H. T., Epstein, A. E., Plumb, V. J., & Kay, G. N. (2007). Electrophysiologic and electrocardiographic characteristics and radiofrequency catheter ablation of focal atrial tachycardia originating from the left atrial appendage. Heart Rhythm, 4(10), 1284-1291. https://doi.org/10.1016/j.hrthm.2007.06.008