Electrophilic substitution in skatole and its derivatives

Wayland E Noland, Donald N. Robinson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Evidence is presented to show that the 2-position is the primary site of electrophilic substitution in skatole and its derivatives. Existing data in the literature are reconciled with this view.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
Issue number1
StatePublished - 1958

Bibliographical note

Funding Information:
l Log 2E. * Research Corporation research assistant, 19X-1957. We are indebted to the Research Corporation for a Frederick Gardner Come11 grant in support of this research. l M. Passerini and T. Bonciani, Guzz. C&m. Ifal. 63, 138 (1933). * V. Dostil, C’hem. Lisrj~ 32, 13 (1938). 8 A. gtienne and R. Heym&s. Bull. SIC. Chim. Fr. 841 (1948). ’ H. van Dobeneck and G. Maresch, Hoppe-Seyl. 2. 289, 271 (1952). s M. Freund and G. Lebach, Ber. Drsch. Chem. Ges. 38, 2440 (1905). 6 P. L. Julian, E. W. Meyer and H. C. Printy, Heterucycfic Compounds (Edited by R. C. Elderfield) Vol. 3, p. 95. Wiley, New York (1952).


Dive into the research topics of 'Electrophilic substitution in skatole and its derivatives'. Together they form a unique fingerprint.

Cite this