Electron transfer from graphene quantum dots to the copper complex enhances its nuclease activity

Bin Zheng, Chong Wang, Xiaozhen Xin, Fei Liu, Xuejiao Zhou, Jingyan Zhang, Shouwu Guo

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We previously reported that graphene oxide could enhance nuclease activity of copper complex containing aromatic ligands, thus exhibit the potential for applications in anticancer therapy. However, the functional mechanism of graphene oxide is not well understood. In this work, using graphene quantum dots (GQDs), which have smaller lateral size, better biocompatibility, and a conjugate state higher than that of graphene oxide, we investigated systematically the mechanism of GQDs in enhancing nuclease activity of copper complexes. Through a variety of spectroscopic methods, we found that GQDs promote the reduction of copper ions and accelerate their reaction with O 2, forming superoxide anions and copper-centered radicals. These active species then oxidize DNA molecules. The improvement in the reduction of copper complexes can be attributed to the coordination of the GQDs to the copper center of the complex, leading to an efficient electron-transfer from the electron-rich GQDs to the copper complexes. The fundamental understanding of the role of the GQDs in DNA cleavage by the transition complexes is promising for the discovery of anticancer therapeutics. More importantly, unique and rich three-dimensional structures of metal complexes also make it possible to prepare highly active DNA cleavage reagents with a high selectivity for DNA sequences and structures.

Original languageEnglish (US)
Pages (from-to)7637-7642
Number of pages6
JournalJournal of Physical Chemistry C
Volume118
Issue number14
DOIs
StatePublished - Apr 10 2014
Externally publishedYes

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