TY - JOUR
T1 - Electron impact and fast atom bombardment mass spectrometric analysis of the food‐borne carcinogens 2‐amino‐3‐methylimidazo [4,5‐f] quinoline, 2‐amino‐3,8‐dimethylimidazo [4,5‐f] quinoxaline and their metabolites
AU - Fay, Laurent B.
AU - Turesky, Robert J.
PY - 1992/9
Y1 - 1992/9
N2 - Electron impact (El) and fast atom bombardment (FAB) mass spectrometry were used to characterize the hetero‐cyclic aromatic amines, 2‐amino‐3‐methylimidazo [4,5‐f] quinoline and 2‐amino‐3,8‐dimethylimidazo [4,5‐f] quinoxaline and their metabolites. The carcinogenic N2‐hydroxy metabolites and several non‐conjugated detoxification products were analysed directly by El mass spectrometry, while several polar sulphate and β‐glucuronic acid conjugates were analysed by FAB mass spectrometry. Analysis of β‐glucuronic acid conjugates was also achieved by El mass spectrometry following silylation.
AB - Electron impact (El) and fast atom bombardment (FAB) mass spectrometry were used to characterize the hetero‐cyclic aromatic amines, 2‐amino‐3‐methylimidazo [4,5‐f] quinoline and 2‐amino‐3,8‐dimethylimidazo [4,5‐f] quinoxaline and their metabolites. The carcinogenic N2‐hydroxy metabolites and several non‐conjugated detoxification products were analysed directly by El mass spectrometry, while several polar sulphate and β‐glucuronic acid conjugates were analysed by FAB mass spectrometry. Analysis of β‐glucuronic acid conjugates was also achieved by El mass spectrometry following silylation.
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U2 - 10.1002/bms.1200210907
DO - 10.1002/bms.1200210907
M3 - Article
C2 - 1420382
AN - SCOPUS:0026924824
SN - 1052-9306
VL - 21
SP - 463
EP - 469
JO - Biological Mass Spectrometry
JF - Biological Mass Spectrometry
IS - 9
ER -