Electron impact and fast atom bombardment mass spectrometric analysis of the food‐borne carcinogens 2‐amino‐3‐methylimidazo [4,5‐f] quinoline, 2‐amino‐3,8‐dimethylimidazo [4,5‐f] quinoxaline and their metabolites

Laurent B. Fay, Robert J. Turesky

Research output: Contribution to journalArticle

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Abstract

Electron impact (El) and fast atom bombardment (FAB) mass spectrometry were used to characterize the hetero‐cyclic aromatic amines, 2‐amino‐3‐methylimidazo [4,5‐f] quinoline and 2‐amino‐3,8‐dimethylimidazo [4,5‐f] quinoxaline and their metabolites. The carcinogenic N2‐hydroxy metabolites and several non‐conjugated detoxification products were analysed directly by El mass spectrometry, while several polar sulphate and β‐glucuronic acid conjugates were analysed by FAB mass spectrometry. Analysis of β‐glucuronic acid conjugates was also achieved by El mass spectrometry following silylation.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalBiological Mass Spectrometry
Volume21
Issue number9
DOIs
StatePublished - Sep 1992

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