Electroconvulsive therapy for depression in Parkinson's disease: systematic review of evidence and recommendations

Anna Borisovskaya, William Culbertson Bryson, Jonathan Buchholz, Ali Samii, Soo Borson

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

AIM: We performed a systematic review of evidence regarding treatment of depression in Parkinson's disease (PD) utilizing electroconvulsive therapy.

METHODS: The search led to the inclusion of 43 articles, mainly case reports or case series, with the largest number of patients totaling 19.

RESULTS: The analysis included 116 patients with depression and PD; depression improved in 93.1%. Where motor symptoms' severity was reported, 83% of patients improved. Cognition did not worsen in the majority (94%). Many patients experienced delirium or transient confusion, sometimes necessitating discontinuation of electroconvulsive therapy (ECT). Little is known about maintenance ECT in this population.

CONCLUSION: ECT can benefit patients suffering from PD and depression. We recommend an algorithm for treatment of depression in PD, utilizing ECT sooner rather than later.

Original languageEnglish (US)
Pages (from-to)161-176
Number of pages16
JournalNeurodegenerative disease management
Volume6
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • electroconvulsive therapy
  • major depressive disorder
  • Parkinson's disease

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