Electrochemical direct detection of DNA deamination catalyzed by APOBEC3G

Junya Chiba, Takahide Kouno, Shun Aoki, Hitoshi Sato, Jingying Zhang, Hiroshi Matsuo, Masahiko Inouye

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

APOBEC3G catalyzes deamination of cytosines in HIV-1 genome, and restricts the HIV-1 infection. Here, we propose a picomole-scale assay for the detection of DNA deamination catalyzed by APOBEC3G. Our results show the suitability of the developed method for a time course analysis of enzyme-catalyzed DNA modifications.

Original languageEnglish (US)
Pages (from-to)12115-12117
Number of pages3
JournalChemical Communications
Volume48
Issue number99
DOIs
StatePublished - Nov 19 2012

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