Electrocardiographic changes after bilateral carotid sinus denervation in the rat

H. R. Baur, C. A. Pierach

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3 Scopus citations


The effect of bilateral carotid sinus denervation (CSD) on the ECG and on the monophasic ventricular action potential (MAP) was studied in 28 and 4 rats, respectively. After CSD, T wave changes, similar to those seen in man after carotid endarterectomy, were observed and mean Q-T prolongations of 19 ms were recorded (P < 0.001). Mean MAP increased by 10 ms (P < 0.02). P-QRS and heart rate remained stable. Propranolol, 10 mg/kg iv, before CSD and 10 mg kg-1 day-1 iv for 2 days prevented all ECG abnormalities. Atropine, 1 mg/kg iv, before CSD and 2.5 mg kg-1 day-1 iv for 2 days had no effect. Isoproterenol, 0.02-0.06 μg iv, after CSD produced further lengthening of the MAP and Q-T interval. Blood gases and electrolytes remained unchanged, and cardiac histology was unremarkable. These results suggest that CSD produces alterations in cardiac sympathetic activity in the rat leading to MAP and Q-T prolongations and to changes in the T wave form. Similar mechanisms may be operative after carotid endarterectomy in man.

Original languageEnglish (US)
Pages (from-to)H475-H480
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number4
StatePublished - 1979


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