TY - JOUR
T1 - Electroactive controlled release thin films
AU - Wood, Kris C.
AU - Zacharia, Nicole S.
AU - Schmidt, Daniel J.
AU - Wrightman, Stefani N.
AU - Andaya, Brian J.
AU - Hammond, Paula T.
PY - 2008/2/19
Y1 - 2008/2/19
N2 - We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their contents after the application of a voltage and then to restabilize upon its removal. As a result, it is possible to externally trigger agent release, exert control over the relative quantity of agents released from a film, and release multiple doses from one or more films in a single solution. These electroactive systems may be rapidly and conformally coated onto a wide range of substrates without regard to size, shape, or chemical composition, and as such they may find use in a host of new applications in drug delivery as well as the related fields of tissue engineering, medical diagnostics, and chemical detection.
AB - We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their contents after the application of a voltage and then to restabilize upon its removal. As a result, it is possible to externally trigger agent release, exert control over the relative quantity of agents released from a film, and release multiple doses from one or more films in a single solution. These electroactive systems may be rapidly and conformally coated onto a wide range of substrates without regard to size, shape, or chemical composition, and as such they may find use in a host of new applications in drug delivery as well as the related fields of tissue engineering, medical diagnostics, and chemical detection.
KW - Drug delivery
KW - Layer-by-layer thin film
KW - Polymer
KW - Prussian blue
KW - Responsive materials
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U2 - 10.1073/pnas.0706994105
DO - 10.1073/pnas.0706994105
M3 - Article
C2 - 18272499
AN - SCOPUS:40649114986
SN - 0027-8424
VL - 105
SP - 2280
EP - 2285
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -