TY - JOUR
T1 - Electric communication between the inner part of a cell and an electrode
T2 - The way to look inside a cell
AU - Meng, Fanben
AU - Yang, Jinghua
AU - Liu, Tao
AU - Zhu, Xiaoli
AU - Li, Genxi
PY - 2009/11/1
Y1 - 2009/11/1
N2 - A strategy to assemble cells on a solid support surface, here the surface of a gold electrode, is developed by transfecting cells with thiolated DNA molecules which have been immobilized on the gold electrode surface in advance. This strategy to assemble cells can present a general and convenient method for cell assembly on a solid support surface. What is more interesting, since efficient electric communication via the thiolated DNA between the electroactive species inside the cells and the substrate electrode can be achieved, an approach to "look" into the inner part of the cells is proposed. For the test in this work, one drug, kaempferol, and one dye molecule, methylene blue, inside the cells have been detected by the commonly used electrochemical method linear scan voltammetry, and satisfactory results have been obtained.
AB - A strategy to assemble cells on a solid support surface, here the surface of a gold electrode, is developed by transfecting cells with thiolated DNA molecules which have been immobilized on the gold electrode surface in advance. This strategy to assemble cells can present a general and convenient method for cell assembly on a solid support surface. What is more interesting, since efficient electric communication via the thiolated DNA between the electroactive species inside the cells and the substrate electrode can be achieved, an approach to "look" into the inner part of the cells is proposed. For the test in this work, one drug, kaempferol, and one dye molecule, methylene blue, inside the cells have been detected by the commonly used electrochemical method linear scan voltammetry, and satisfactory results have been obtained.
UR - http://www.scopus.com/inward/record.url?scp=70350637315&partnerID=8YFLogxK
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U2 - 10.1021/ac901455n
DO - 10.1021/ac901455n
M3 - Article
C2 - 19795896
AN - SCOPUS:70350637315
SN - 0003-2700
VL - 81
SP - 9168
EP - 9171
JO - Analytical chemistry
JF - Analytical chemistry
IS - 21
ER -