Abstract
Treatment of psoriasis with psoralens and high-intensity long-wave ultraviolet light (PUVA) produces changes in the ultrastructure of elastic tissue in skin. Early alterations consist of a loss of elastin followed by a breakdown of the microfibrils and subsequent fragmentation of the elastic fiber. Tissue examined 15 months after treatment was stopped still showed marked ultrastructural changes in the elastic fibers.
Original language | English (US) |
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Pages (from-to) | 186-192 |
Number of pages | 7 |
Journal | Journal of the American Academy of Dermatology |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 1980 |
Externally published | Yes |
Bibliographical note
Funding Information:Supported by United States Public Health Service Grant 1 ROI-AM-21681, lips Foundatoni and the McKnight Foundonati.