Treatment of psoriasis with psoralens and high-intensity long-wave ultraviolet light (PUVA) produces changes in the ultrastructure of elastic tissue in skin. Early alterations consist of a loss of elastin followed by a breakdown of the microfibrils and subsequent fragmentation of the elastic fiber. Tissue examined 15 months after treatment was stopped still showed marked ultrastructural changes in the elastic fibers.
Bibliographical noteFunding Information:
Supported by United States Public Health Service Grant 1 ROI-AM-21681, lips Foundatoni and the McKnight Foundonati.