Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
Bibliographical notePublisher Copyright:
© 2021 Elsevier Ltd
PubMed: MeSH publication types
- Journal Article