Efficient solid phase synthesis of 3,5-disubstituted hydantoins

Adel Nefzi, John M. Ostresh, Marc Giulianotti, Richard A. Houghten

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


An efficient solid phase synthesis of 3,5-disubstituted hydantoins is described. The treatment of a resin-bound diamino acid containing dipeptide with carbonyldiimidazole or triphosgene afforded the five member ring hydantoins. A second site of diversity is included following N-acylation of the free amine side chain with a wide range of commercially available carboxylic acids.

Original languageEnglish (US)
Pages (from-to)8199-8202
Number of pages4
JournalTetrahedron Letters
Issue number45
StatePublished - Nov 5 1998
Externally publishedYes

Bibliographical note

Funding Information:
We thank Eileen Weiler for editorial assistance. This work was funded by Tresa Biosciences, Inc. and National

Funding Information:
Science Foundation Grant No. CHE-9520 \]4 2 Oloughten).


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