Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP

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Abstract

The direct alkynylation of tautomerizable heterocylcles is described via a two-step process involving in situ C-OH activation with bromotripyrrolidinophosphonium hexafluorophosphate (PyBrOP) followed by Sonogashira coupling with a wide range of alkyl or aryl terminal alkynes using a copper-free system employing PdCl2(CH3CN)2 and 2-(dicyclohexylphosphino)biphenyl.

Original languageEnglish (US)
Pages (from-to)2286-2289
Number of pages4
JournalOrganic Letters
Volume12
Issue number10
DOIs
StatePublished - May 21 2010

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