Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: A VA cooperative study

Geoffrey J. Gorse, Theresa Z. O'Connor, Stephen L. Young, Paul M. Mendelman, Suzanne F. Bradley, Kristin L. Nichol, James H. Strickland, Daniel M. Paulson, Kathryn L. Rice, Runi A. Foster, Ashok M. Fulambarker, John W. Shigeoka, Ware G. Kuschner, Richard P. Goodman, Kathleen M. Neuzil, Janet Wittes, Kathy D. Boardman, Peter N. Peduzzi

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): -0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: -0.17, 0.53), and -0.05 for type B virus (95% CL: -1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study.

Original languageEnglish (US)
Pages (from-to)2133-2144
Number of pages12
JournalVaccine
Volume21
Issue number17-18
DOIs
StatePublished - May 16 2003

Keywords

  • Efficacy
  • Influenza vaccine
  • Influenza virus

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    Gorse, G. J., O'Connor, T. Z., Young, S. L., Mendelman, P. M., Bradley, S. F., Nichol, K. L., Strickland, J. H., Paulson, D. M., Rice, K. L., Foster, R. A., Fulambarker, A. M., Shigeoka, J. W., Kuschner, W. G., Goodman, R. P., Neuzil, K. M., Wittes, J., Boardman, K. D., & Peduzzi, P. N. (2003). Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: A VA cooperative study. Vaccine, 21(17-18), 2133-2144. https://doi.org/10.1016/S0264-410X(02)00748-X