Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin

Talha Badar; Mehdi Hamadani; Veronika Bachanova; Kami J. Maddocks; Elvira Umyarova; Julio C. Chavez; Narendranath Epperla; Saurabh Chhabra; Ana C. Xavier; Reem Karmali; Mohammed Salhab; Nishitha Reddy; Martha J. Glenn; Francisco J. Hernandez-Ilizaliturri; Christopher R. Flowers; Andrew M. Evens; Zheng Zhou; Frederick Lansigan; Stefan K. Barta; Jonathon B. Cohen; Timothy S. Fenske; Luciano J. Costa

doi:10.1080/10428194.2018.1515944

Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin

Talha Badar, Mehdi Hamadani, Veronika Bachanova, Kami J. Maddocks, Elvira Umyarova, Julio C. Chavez, Narendranath Epperla, Saurabh Chhabra, Ana C. Xavier, Reem Karmali, Mohammed Salhab, Nishitha Reddy, Martha J. Glenn, Francisco J. Hernandez-Ilizaliturri, Christopher R. Flowers, Andrew M. Evens, Zheng Zhou, Frederick Lansigan, Stefan K. Barta, Jonathon B. CohenTimothy S. Fenske, Luciano J. Costa

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2 Scopus citations

Abstract

We evaluated outcome of 235 primary treatment failure (PTF) diffuse large B-cell lymphoma (DLBCL) patients based on salvage chemotherapy regimen and putative cell-of-origin (COO). Patients were divided into two groups; group A (n = 38) received high-dose cytarabine containing regimen, either DHAP or ESHAP. Patients in group B (n = 197) received ifosfamide, carboplatin, and etoposide (ICE) +/− rituximab. No difference in overall response rates (CR + PR) was observed based on salvage chemotherapy regimen and COO. After adjustment for the presence of ultra high-risk features, overall survival of germinal center B-cell like (GCB) DLBCL patients in group A was not significantly different from survival in group B (HR 0.86, 95% CI 0.46–1.60, p =.64). Similarly, within non-GCB DLBCL cohort, survival in group A was comparable to group B (HR 0.53, 95% CI 0.20–1.44, p =.21). We did not find an outcome difference between two commonly used salvage chemotherapy regimens in patients with PTF DLBCL based on COO.

Original language	English (US)
Pages (from-to)	940-946
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	60
Issue number	4
DOIs	https://doi.org/10.1080/10428194.2018.1515944
State	Published - Mar 21 2019

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Refractory diffuse large B-cell lymphoma
germinal center B-cell like DLBCL
putative cell-of-origin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2018.1515944

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Badar, T., Hamadani, M., Bachanova, V., Maddocks, K. J., Umyarova, E., Chavez, J. C., Epperla, N., Chhabra, S., Xavier, A. C., Karmali, R., Salhab, M., Reddy, N., Glenn, M. J., Hernandez-Ilizaliturri, F. J., Flowers, C. R., Evens, A. M., Zhou, Z., Lansigan, F., Barta, S. K., ... Costa, L. J. (2019). Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin. Leukemia and Lymphoma, 60(4), 940-946. https://doi.org/10.1080/10428194.2018.1515944

Badar, T, Hamadani, M, Bachanova, V, Maddocks, KJ, Umyarova, E, Chavez, JC, Epperla, N, Chhabra, S, Xavier, AC, Karmali, R, Salhab, M, Reddy, N, Glenn, MJ, Hernandez-Ilizaliturri, FJ, Flowers, CR, Evens, AM, Zhou, Z, Lansigan, F, Barta, SK, Cohen, JB, Fenske, TS & Costa, LJ 2019, 'Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin', Leukemia and Lymphoma, vol. 60, no. 4, pp. 940-946. https://doi.org/10.1080/10428194.2018.1515944

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title = "Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin",

abstract = "We evaluated outcome of 235 primary treatment failure (PTF) diffuse large B-cell lymphoma (DLBCL) patients based on salvage chemotherapy regimen and putative cell-of-origin (COO). Patients were divided into two groups; group A (n = 38) received high-dose cytarabine containing regimen, either DHAP or ESHAP. Patients in group B (n = 197) received ifosfamide, carboplatin, and etoposide (ICE) +/− rituximab. No difference in overall response rates (CR + PR) was observed based on salvage chemotherapy regimen and COO. After adjustment for the presence of ultra high-risk features, overall survival of germinal center B-cell like (GCB) DLBCL patients in group A was not significantly different from survival in group B (HR 0.86, 95% CI 0.46–1.60, p =.64). Similarly, within non-GCB DLBCL cohort, survival in group A was comparable to group B (HR 0.53, 95% CI 0.20–1.44, p =.21). We did not find an outcome difference between two commonly used salvage chemotherapy regimens in patients with PTF DLBCL based on COO.",

keywords = "Refractory diffuse large B-cell lymphoma, germinal center B-cell like DLBCL, putative cell-of-origin",

author = "Talha Badar and Mehdi Hamadani and Veronika Bachanova and Maddocks, {Kami J.} and Elvira Umyarova and Chavez, {Julio C.} and Narendranath Epperla and Saurabh Chhabra and Xavier, {Ana C.} and Reem Karmali and Mohammed Salhab and Nishitha Reddy and Glenn, {Martha J.} and Hernandez-Ilizaliturri, {Francisco J.} and Flowers, {Christopher R.} and Evens, {Andrew M.} and Zheng Zhou and Frederick Lansigan and Barta, {Stefan K.} and Cohen, {Jonathon B.} and Fenske, {Timothy S.} and Costa, {Luciano J.}",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2019",

month = mar,

day = "21",

doi = "10.1080/10428194.2018.1515944",

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T1 - Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin

AU - Badar, Talha

AU - Hamadani, Mehdi

AU - Bachanova, Veronika

AU - Maddocks, Kami J.

AU - Umyarova, Elvira

AU - Chavez, Julio C.

AU - Epperla, Narendranath

AU - Chhabra, Saurabh

AU - Xavier, Ana C.

AU - Karmali, Reem

AU - Salhab, Mohammed

AU - Reddy, Nishitha

AU - Glenn, Martha J.

AU - Hernandez-Ilizaliturri, Francisco J.

AU - Flowers, Christopher R.

AU - Evens, Andrew M.

AU - Zhou, Zheng

AU - Lansigan, Frederick

AU - Barta, Stefan K.

AU - Cohen, Jonathon B.

AU - Fenske, Timothy S.

AU - Costa, Luciano J.

PY - 2019/3/21

Y1 - 2019/3/21

N2 - We evaluated outcome of 235 primary treatment failure (PTF) diffuse large B-cell lymphoma (DLBCL) patients based on salvage chemotherapy regimen and putative cell-of-origin (COO). Patients were divided into two groups; group A (n = 38) received high-dose cytarabine containing regimen, either DHAP or ESHAP. Patients in group B (n = 197) received ifosfamide, carboplatin, and etoposide (ICE) +/− rituximab. No difference in overall response rates (CR + PR) was observed based on salvage chemotherapy regimen and COO. After adjustment for the presence of ultra high-risk features, overall survival of germinal center B-cell like (GCB) DLBCL patients in group A was not significantly different from survival in group B (HR 0.86, 95% CI 0.46–1.60, p =.64). Similarly, within non-GCB DLBCL cohort, survival in group A was comparable to group B (HR 0.53, 95% CI 0.20–1.44, p =.21). We did not find an outcome difference between two commonly used salvage chemotherapy regimens in patients with PTF DLBCL based on COO.

AB - We evaluated outcome of 235 primary treatment failure (PTF) diffuse large B-cell lymphoma (DLBCL) patients based on salvage chemotherapy regimen and putative cell-of-origin (COO). Patients were divided into two groups; group A (n = 38) received high-dose cytarabine containing regimen, either DHAP or ESHAP. Patients in group B (n = 197) received ifosfamide, carboplatin, and etoposide (ICE) +/− rituximab. No difference in overall response rates (CR + PR) was observed based on salvage chemotherapy regimen and COO. After adjustment for the presence of ultra high-risk features, overall survival of germinal center B-cell like (GCB) DLBCL patients in group A was not significantly different from survival in group B (HR 0.86, 95% CI 0.46–1.60, p =.64). Similarly, within non-GCB DLBCL cohort, survival in group A was comparable to group B (HR 0.53, 95% CI 0.20–1.44, p =.21). We did not find an outcome difference between two commonly used salvage chemotherapy regimens in patients with PTF DLBCL based on COO.

KW - Refractory diffuse large B-cell lymphoma

KW - germinal center B-cell like DLBCL

KW - putative cell-of-origin

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EP - 946

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

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ER -

Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin

Abstract

Bibliographical note

Keywords

UN SDGs

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