TY - JOUR
T1 - Efficacy of parathyroid hormone supplementation on the osseointegration of implants
T2 - a systematic review
AU - Javed, Fawad
AU - Al Amri, Mohammad D.
AU - Kellesarian, Sergio Varela
AU - Al-Kheraif, Abdulaziz A.
AU - Vohra, Fahim
AU - Calvo-Guirado, José Luis
AU - Malmstrom, Hans
AU - Romanos, Georgios E.
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Objective: The aim of the present systematic review was to assess the efficacy of parathyroid hormone supplementation on the osseointegration of implants. Methods: The addressed focused question was Does parathyroid hormone supplementation affect osseointegration around implants? Indexed databases were searched from 1965 up to and including April 2015 using various key words including: Bone to implant contact; implant; parathyroid hormone; and osseointegration. Letters to the Editor, case-reports/case-series, historic reviews, commentaries and articles published in languages other than English were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data. Results: Eighteen studies fulfilled the eligibility criteria. Evidence was limited to preclinical animal studies only (11 studies in rodents, 4 in dogs and 3 in rabbits). Number of titanium implants placed ranged between 20 and 80 implants. Results from 16 studies showed that PTH supplementation enhanced new bone formation and/or BIC around implants. One study suggests that PTH-coated implants improve BIC and BA. One study showed no significant difference in BIC and new bone formation around implants with PTH hydrogel placement. Conclusion: Efficacy of PTH supplementation on osseointegration of implants shows promising results in animal models, however further investigation is necessary to assess the effectiveness in humans.
AB - Objective: The aim of the present systematic review was to assess the efficacy of parathyroid hormone supplementation on the osseointegration of implants. Methods: The addressed focused question was Does parathyroid hormone supplementation affect osseointegration around implants? Indexed databases were searched from 1965 up to and including April 2015 using various key words including: Bone to implant contact; implant; parathyroid hormone; and osseointegration. Letters to the Editor, case-reports/case-series, historic reviews, commentaries and articles published in languages other than English were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data. Results: Eighteen studies fulfilled the eligibility criteria. Evidence was limited to preclinical animal studies only (11 studies in rodents, 4 in dogs and 3 in rabbits). Number of titanium implants placed ranged between 20 and 80 implants. Results from 16 studies showed that PTH supplementation enhanced new bone formation and/or BIC around implants. One study suggests that PTH-coated implants improve BIC and BA. One study showed no significant difference in BIC and new bone formation around implants with PTH hydrogel placement. Conclusion: Efficacy of PTH supplementation on osseointegration of implants shows promising results in animal models, however further investigation is necessary to assess the effectiveness in humans.
KW - Bone to implant contact
KW - Implant
KW - Osseointegration
KW - Parathyroid hormone
UR - https://www.scopus.com/pages/publications/84964444642
UR - https://www.scopus.com/pages/publications/84964444642#tab=citedBy
U2 - 10.1007/s00784-015-1691-1
DO - 10.1007/s00784-015-1691-1
M3 - Review article
C2 - 26689569
AN - SCOPUS:84964444642
SN - 1432-6981
VL - 20
SP - 649
EP - 658
JO - Clinical oral investigations
JF - Clinical oral investigations
IS - 4
ER -