Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma

John F. De Groot, Albert H. Kim, Sujit Prabhu, Ganesh Rao, Adrian W. Laxton, Peter E. Fecci, Barbara J. O'Brien, Andrew Sloan, Veronica Chiang, Stephen B. Tatter, Alireza M. Mohammadi, Dimitris G. Placantonakis, Roy E. Strowd, Clark Chen, Constantinos Hadjipanayis, Mustafa Khasraw, David Sun, David Piccioni, Kaylyn D. Sinicrope, Jian L. CampianSylvia C. Kurz, Brian Williams, Kris Smith, Zulma Tovar-Spinoza, Eric C. Leuthardt

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors. The LAANTERN prospective multicenter registry (NCT02392078) data were analyzed to determine clinical outcomes for patients with new and recurrent IDH wild-type glioblastoma.

Methods: Demographics, intraprocedural data, adverse events, KPS, health economics, and survival data were prospectively collected and then analyzed on IDH wild-type newly diagnosed and recurrent glioblastoma patients who were treated with laser ablation at 14 US centers between January 2016 and May 2019. Data were monitored for accuracy. Statistical analysis included individual variable summaries, multivariable differences in survival, and median survival numbers.

Results: A total of 29 new and 60 recurrent IDH wild-type WHO grade 4 glioblastoma patients were treated. Positive MGMT promoter methylation status was present in 5/29 of new and 23/60 of recurrent patients. Median physician-estimated extent of ablation was 91%-99%. Median overall survival (OS) was 9.73 months (95% confidence interval: 5.16, 15.91) for newly diagnosed patients and median post-procedure survival was 8.97 months (6.94, 12.36) for recurrent patients. Median OS for newly diagnosed patients receiving post-LITT chemo/radiation was 16.14 months (6.11, not reached). Factors associated with improved survival were MGMT promoter methylation, adjuvant chemotherapy within 12 weeks, and tumor volume <3 cc.

Conclusions: Laser ablation is a viable option for patients with new and recurrent glioblastoma. Median OS for IDH wild-type newly diagnosed glioblastoma is comparable to outcomes observed in other tumor resection studies when those patients undergo radiation and chemotherapy following LITT.

Original languageEnglish (US)
Article numbervdac040
JournalNeuro-Oncology Advances
Issue number1
StatePublished - Jan 1 2022

Bibliographical note

Funding Information:
The LAANTERN registry study is sponsored by Monteris Medical Inc. ClinicalTrials.gov study ID #NCT02392078.

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.


  • IDH wild-type WHO grade 4 glioblastoma
  • high-grade glioma
  • laser interstitial thermal therapy (LITT)
  • primary brain tumor
  • stereotactic laser ablation (SLA)


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