TY - JOUR
T1 - Efficacy of Endoscopic Full Thickness Resection Using the Full-Thickness Resection Device for Submucosal Invasive Colorectal Cancer
T2 - The First United States Multicenter Experience
AU - Karna, Rahul
AU - Mahmood, Syed Kashif
AU - Phan, Jennifer
AU - Inamdar, Sumant
AU - Ladd, Antonio Mendoza
AU - Oza, Veeral M.
AU - Girotra, Mohit
AU - Khara, Harshit
AU - Wilson, Natalie J
AU - Azeem, Nabeel
AU - Bilal, Mohammad
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
PY - 2025
Y1 - 2025
N2 - Purpose: Endoscopic full-thickness resection (EFTR) using full thickness resection device is used for removal of non-lifting or previously manipulated polyps. There is limited data regarding its efficacy for removal of colorectal submucosal invasive cancer (SMIC). Methods: We conducted retrospective multicenter study on patients who underwent EFTR using full thickness resection device for suspected or biopsy proven colorectal cancer (CRC). Results: Technical success was 100% and R0 resection rate was 85%. Overall, 6/20 were referred for surgery due to high risk features. Curative resection rate was 46.7% (7/15) in T1 CRC. Adverse events included 1 bleeding and 1 perforation, managed endoscopically and 1 bleeding and 2 post-polypectomy syndromes managed conservatively. Conclusions: Our series provides the first multicenter experience on EFTR for resection of colorectal SMIC from the United States. Longitudinal data from large scale studies are required to validate our initial experience of EFTR for SMIC.
AB - Purpose: Endoscopic full-thickness resection (EFTR) using full thickness resection device is used for removal of non-lifting or previously manipulated polyps. There is limited data regarding its efficacy for removal of colorectal submucosal invasive cancer (SMIC). Methods: We conducted retrospective multicenter study on patients who underwent EFTR using full thickness resection device for suspected or biopsy proven colorectal cancer (CRC). Results: Technical success was 100% and R0 resection rate was 85%. Overall, 6/20 were referred for surgery due to high risk features. Curative resection rate was 46.7% (7/15) in T1 CRC. Adverse events included 1 bleeding and 1 perforation, managed endoscopically and 1 bleeding and 2 post-polypectomy syndromes managed conservatively. Conclusions: Our series provides the first multicenter experience on EFTR for resection of colorectal SMIC from the United States. Longitudinal data from large scale studies are required to validate our initial experience of EFTR for SMIC.
KW - Endoscopic full thickness resection
KW - Endoscopic resection
KW - Full thickness resection device
KW - Malignant polyps
UR - https://www.scopus.com/pages/publications/105019755659
UR - https://www.scopus.com/pages/publications/105019755659#tab=citedBy
U2 - 10.1007/s10620-025-09502-0
DO - 10.1007/s10620-025-09502-0
M3 - Article
C2 - 41144225
AN - SCOPUS:105019755659
SN - 0163-2116
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
ER -
