Efficacy of cell-based therapies for traumatic brain injuries

Matthew R Chrostek, Emily G. Fellows, Winston L. Guo, William J. Swanson, Andrew T. Crane, Maxim C. Cheeran, Walter C. Low, Andrew W. Grande

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Traumatic brain injuries (TBIs) are a leading cause of death and disability. Additionally, growing evidence suggests a link between TBI-induced neuroinflammation and neurodegenerative disorders. Treatments for TBI patients are limited, largely focused on rehabilitation therapy, and ultimately, fail to provide long-term neuroprotective or neurorestorative benefits. Because of the prevalence of TBI and lack of viable treatments, new therapies are needed which can promote neurological recovery. Cell-based treatments are a promising avenue because of their potential to provide multiple therapeutic benefits. Cell-based therapies can promote neuroprotection via modulation of inflammation and promote neurorestoration via induction of angiogenesis and neurogenesis. Neural stem/progenitor cell transplantations have been investigated in preclinical TBI models for their ability to directly contribute to neuroregeneration, form neural-like cells, and improve recovery. Mesenchymal stem cells (MSCs) have been investigated in clinical trials through multiple different routes of administration. Intravenous administration of MSCs appears most promising, demonstrating a robust safety profile, correlation with neurological improvements, and reductions in systemic inflammation following TBI. While still preliminary, evidence suggests cell-based therapies may become a viable treatment for TBI based on their ability to promote neuroregeneration and reduce inflammation.

Original languageEnglish (US)
Article number270
JournalBrain Sciences
Volume9
Issue number10
DOIs
StatePublished - Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Inflammation
  • Mesenchymal stem cells
  • Neural stem cells
  • Neuroregeneration
  • Stem cells
  • Traumatic brain injury

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