Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial

Jawad H. Butt, Pardeep S. Jhund, Jan Belohlávek, Rudolf A. De Boer, Chern En Chiang, Akshai S. Desai, Jarosław Drożdż, Adrian F. Hernandez, Silvio E. Inzucchi, Tzvetana Katova, Masafumi Kitakaze, Mikhail N. Kosiborod, Carolyn S.P. Lam, Anna Maria Langkilde, Daniel Lindholm, Erasmus Bachus, Felipe Martinez, Béla Merkely, Magnus Petersson, Jose F.Kerr SaraivaSanjiv J. Shah, Muthiah Vaduganathan, Orly Vardeny, Ulrica Wilderäng, Brian C. Claggett, Scott D. Solomon, John J.V. McMurray

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Background: Frailty is increasing in prevalence. Because patients with frailty are often perceived to have a less favorable risk/benefit profile, they may be less likely to receive new pharmacologic treatments. We investigated the efficacy and tolerability of dapagliflozin according to frailty status in patients with heart failure with mildly reduced or preserved ejection fraction randomized in DELIVER (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure). Methods: Frailty was measured using the Rockwood cumulative deficit approach. The primary end point was time to a first worsening heart failure event or cardiovascular death. Results: Of the 6263 patients randomized, a frailty index (FI) was calculable in 6258. In total, 2354 (37.6%) patients had class 1 frailty (FI ≤0.210; ie, not frail), 2413 (38.6%) had class 2 frailty (FI 0.211-0.310; ie, more frail), and 1491 (23.8%) had class 3 frailty (FI ≥0.311; ie, most frail). Greater frailty was associated with a higher rate of the primary end point (per 100 person-years): FI class 1, 6.3 (95% CI 5.7-7.1); class 2, 8.3 (7.5-9.1); and class 3, 13.4 (12.1-14.7; P<0.001). The effect of dapagliflozin (as a hazard ratio) on the primary end point from FI class 1 to 3 was 0.85 (95% CI, 0.68-1.06), 0.89 (0.74-1.08), and 0.74 (0.61-0.91), respectively (Pinteraction=0.40). Although patients with a greater degree of frailty had worse Kansas City Cardiomyopathy Questionnaire scores at baseline, their improvement with dapagliflozin was greater than it was in patients with less frailty: placebo-corrected improvement in Kansas City Cardiomyopathy Questionnaire Overall Summary Score at 4 months in FI class 1 was 0.3 (95% CI, -0.9 to 1.4); in class 2, 1.5 (0.3-2.7); and in class 3, 3.4 (1.7-5.1; Pinteraction=0.021). Adverse reactions and treatment discontinuation, although more frequent in patients with a greater degree of frailty, were not more common with dapagliflozin than with placebo irrespective of frailty class. Conclusions: In DELIVER, frailty was common and associated with worse outcomes. The benefit of dapagliflozin was consistent across the range of frailty studied. The improvement in health-related quality of life with dapagliflozin occurred early and was greater in patients with a higher level of frailty.

Original languageEnglish (US)
Pages (from-to)1210-1224
Number of pages15
JournalCirculation
Volume146
Issue number16
DOIs
StatePublished - Oct 18 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.

Keywords

  • clinical trial
  • dapagliflozin
  • frailty
  • heart failure
  • Stroke Volume
  • Heart Failure/drug therapy
  • Humans
  • Glucosides/adverse effects
  • Quality of Life
  • Benzhydryl Compounds/adverse effects
  • Frailty/epidemiology

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

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