Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease

Maribeth R. Nicholson, Erin Alexander, Sonia Ballal, Zev Davidovics, Michael Docktor, Michael Dole, Jonathan M. Gisser, Alka Goyal, Suchitra K. Hourigan, M. Kyle Jensen, Jess L. Kaplan, Richard Kellermayer, Judith R. Kelsen, Melissa A. Kennedy, Sahil Khanna, Elizabeth D. Knackstedt, Jennifer Lentine, Jeffery D. Lewis, Sonia Michail, Paul D. MitchellMaria Oliva-Hemker, Tiffany Patton, Karen Queliza, Sarah Sidhu, Aliza B. Solomon, David L. Suskind, Madison Weatherly, Steven Werlin, Edwin F. De Zoeten, Stacy A. Kahn, Nur Aktay, Imad Asbah, Mark Bartlett, Mikelle Bassett, David Brumbaugh, Luis Caicedo, Anu Chawla, Maire Conrad, Chelly Dana Dykes, Kelly Grzywacz, Ajay Gulati, Bhaskar Gurram, Jenny Hellman, Art Kastl, Danny Mallon, Nikhil Pai, Brad Pasternak, Ashish S. Patel, Josh Prozialeck, Norelle Reilly, George Russell, Namita Singh, Lesley Small-Harary, Shilpa Sood, Jessica Stumphy, Jill Sullivan, Sabeen Syed, Cebie Titgemeyer, Pete Townsend, Yuhua Zheng

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Children with inflammatory bowel disease [IBD] are disproportionally affected by recurrent Clostridioides difficile infection [rCDI]. Although faecal microbiota transplantation [FMT] has been used with good efficacy in adults with IBD, little is known about outcomes associated with FMT in paediatric IBD. Methods: We performed a retrospective review of FMT at 20 paediatric centres in the USA from March 2012 to March 2020. Children with and without IBD were compared with determined differences in the efficacy of FMT for rCDI. In addition, children with IBD with and without a successful outcome were compared with determined predictors of success. Safety data and IBD-specific outcomes were obtained. Results: A total of 396 paediatric patients, including 148 with IBD, were included. Children with IBD were no less likely to have a successful first FMT then the non-IBD affected cohort [76% vs 81%, p = 0.17]. Among children with IBD, patients were more likely to have a successful FMT if they received FMT with fresh stool [p = 0.03], were without diarrhoea prior to FMT [p = 0.03], or had a shorter time from rCDI diagnosis until FMT [p = 0.04]. Children with a failed FMT were more likely to have clinically active IBD post-FMT [p = 0.002] and 19 [13%] patients had an IBD-related hospitalisation in the 3-month follow-up. Conclusions: Based on the findings from this large US multicentre cohort, the efficacy of FMT for the treatment of rCDI did not differ in children with IBD. Failed FMT among children with IBD was possibly related to the presence of clinically active IBD.

Original languageEnglish (US)
Pages (from-to)768-777
Number of pages10
JournalJournal of Crohn's and Colitis
Issue number5
StatePublished - May 1 2022

Bibliographical note

Funding Information:
This work was supported by Cures Within Reach [PI: Kahn], a National Institute of Allergy and Infectious Diseases K23 award [No. 1K23AI156132-01 to MRN], a National Institute of Child Health and Human Development K23 award [No. K23HD099240 to SKH], and a National Institutes of Health/National Center for Advancing Translational Sciences Grant Support [No. UL1 TR000445] for REDCap [Vanderbilt University]

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn's and Colitis Organisation. All rights reserved.


  • Crohn's disease
  • Ulcerative colitis
  • child
  • microbiome


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