Efficacy and benefits of catheter ablation of ventricular premature complexes in patients younger and older than 65 years of age

Mehmet Akkaya, Henri Roukoz, Selçuk Adabaǧ, Andrew Peter, Jian Ming Li, Venkat Tholakanahalli

Research output: Contribution to journalArticle

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Abstract

Objectives: Catheter ablation of ventricular premature complexes (VPC) improves clinical status and systolic performance of the left ventricle (LV) in a certain subset of patients; however, whether or not VPC ablation is equally effective in younger (≤65 years) and older (>65 years) patients remains unclear. We aimed to assess the clinical benefits of catheter ablation of VPCs in elderly patients. Study design: Fifty-one consecutive patients (66±10 years, 49 male) who underwent catheter ablation for symptomatic VPCs were included into the study. Twenty-seven patients were aged >65 years and 24 patients ≤65 years. Frequency of VPCs per total heart beats by 24-hour Holter monitoring, LV ejection fraction (LVEF) and end-systolic diameters (LVEDD) were evaluated before and 6±3 months after ablation. Results: The pre-ablation 24-hour VPC burden and VPC number were significantly higher in patients >65 years compared to those ≤65 years (31±15.3 vs. 21.9±12.6, p=0.04 and 34493±21226 vs. 23554±13792, p=0.026, respectively). At the follow-up after catheter ablation, the mean VPC burden had decreased to 9.1±10.3% (p<0.001) in patients >65 years and to 3.8±7.1 (p<0.001) in patients ≤65 years. Mean LVEF showed a significant increase in both groups after ablation (43.4±10.4 vs. 51.5±8.2, p=0.005 for age >65 years and 40.8±13.2 vs. 49.5±11.8, p=0.003 for age ≤65 years). The improvement in LVEF was accompanied by a significant decrease in LVEDD (p=0.032 for age >65 years and p=0.047 for ≤65 years). Conclusion: Catheter ablation is effective for treatment of frequent VPCs in all age groups.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalTurk Kardiyoloji Dernegi Arsivi
Volume41
Issue number6
DOIs
StatePublished - Sep 1 2013

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Ventricular Premature Complexes
Catheter Ablation
Heart Ventricles
Ambulatory Electrocardiography
Age Groups

Keywords

  • Catheter ablation
  • Electrocardiography
  • Ventricular dysfunction, left
  • Ventricular premature complexes / physiopathology

Cite this

Efficacy and benefits of catheter ablation of ventricular premature complexes in patients younger and older than 65 years of age. / Akkaya, Mehmet; Roukoz, Henri; Adabaǧ, Selçuk; Peter, Andrew; Li, Jian Ming; Tholakanahalli, Venkat.

In: Turk Kardiyoloji Dernegi Arsivi, Vol. 41, No. 6, 01.09.2013, p. 497-504.

Research output: Contribution to journalArticle

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abstract = "Objectives: Catheter ablation of ventricular premature complexes (VPC) improves clinical status and systolic performance of the left ventricle (LV) in a certain subset of patients; however, whether or not VPC ablation is equally effective in younger (≤65 years) and older (>65 years) patients remains unclear. We aimed to assess the clinical benefits of catheter ablation of VPCs in elderly patients. Study design: Fifty-one consecutive patients (66±10 years, 49 male) who underwent catheter ablation for symptomatic VPCs were included into the study. Twenty-seven patients were aged >65 years and 24 patients ≤65 years. Frequency of VPCs per total heart beats by 24-hour Holter monitoring, LV ejection fraction (LVEF) and end-systolic diameters (LVEDD) were evaluated before and 6±3 months after ablation. Results: The pre-ablation 24-hour VPC burden and VPC number were significantly higher in patients >65 years compared to those ≤65 years (31±15.3 vs. 21.9±12.6, p=0.04 and 34493±21226 vs. 23554±13792, p=0.026, respectively). At the follow-up after catheter ablation, the mean VPC burden had decreased to 9.1±10.3{\%} (p<0.001) in patients >65 years and to 3.8±7.1 (p<0.001) in patients ≤65 years. Mean LVEF showed a significant increase in both groups after ablation (43.4±10.4 vs. 51.5±8.2, p=0.005 for age >65 years and 40.8±13.2 vs. 49.5±11.8, p=0.003 for age ≤65 years). The improvement in LVEF was accompanied by a significant decrease in LVEDD (p=0.032 for age >65 years and p=0.047 for ≤65 years). Conclusion: Catheter ablation is effective for treatment of frequent VPCs in all age groups.",
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T1 - Efficacy and benefits of catheter ablation of ventricular premature complexes in patients younger and older than 65 years of age

AU - Akkaya, Mehmet

AU - Roukoz, Henri

AU - Adabaǧ, Selçuk

AU - Peter, Andrew

AU - Li, Jian Ming

AU - Tholakanahalli, Venkat

PY - 2013/9/1

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N2 - Objectives: Catheter ablation of ventricular premature complexes (VPC) improves clinical status and systolic performance of the left ventricle (LV) in a certain subset of patients; however, whether or not VPC ablation is equally effective in younger (≤65 years) and older (>65 years) patients remains unclear. We aimed to assess the clinical benefits of catheter ablation of VPCs in elderly patients. Study design: Fifty-one consecutive patients (66±10 years, 49 male) who underwent catheter ablation for symptomatic VPCs were included into the study. Twenty-seven patients were aged >65 years and 24 patients ≤65 years. Frequency of VPCs per total heart beats by 24-hour Holter monitoring, LV ejection fraction (LVEF) and end-systolic diameters (LVEDD) were evaluated before and 6±3 months after ablation. Results: The pre-ablation 24-hour VPC burden and VPC number were significantly higher in patients >65 years compared to those ≤65 years (31±15.3 vs. 21.9±12.6, p=0.04 and 34493±21226 vs. 23554±13792, p=0.026, respectively). At the follow-up after catheter ablation, the mean VPC burden had decreased to 9.1±10.3% (p<0.001) in patients >65 years and to 3.8±7.1 (p<0.001) in patients ≤65 years. Mean LVEF showed a significant increase in both groups after ablation (43.4±10.4 vs. 51.5±8.2, p=0.005 for age >65 years and 40.8±13.2 vs. 49.5±11.8, p=0.003 for age ≤65 years). The improvement in LVEF was accompanied by a significant decrease in LVEDD (p=0.032 for age >65 years and p=0.047 for ≤65 years). Conclusion: Catheter ablation is effective for treatment of frequent VPCs in all age groups.

AB - Objectives: Catheter ablation of ventricular premature complexes (VPC) improves clinical status and systolic performance of the left ventricle (LV) in a certain subset of patients; however, whether or not VPC ablation is equally effective in younger (≤65 years) and older (>65 years) patients remains unclear. We aimed to assess the clinical benefits of catheter ablation of VPCs in elderly patients. Study design: Fifty-one consecutive patients (66±10 years, 49 male) who underwent catheter ablation for symptomatic VPCs were included into the study. Twenty-seven patients were aged >65 years and 24 patients ≤65 years. Frequency of VPCs per total heart beats by 24-hour Holter monitoring, LV ejection fraction (LVEF) and end-systolic diameters (LVEDD) were evaluated before and 6±3 months after ablation. Results: The pre-ablation 24-hour VPC burden and VPC number were significantly higher in patients >65 years compared to those ≤65 years (31±15.3 vs. 21.9±12.6, p=0.04 and 34493±21226 vs. 23554±13792, p=0.026, respectively). At the follow-up after catheter ablation, the mean VPC burden had decreased to 9.1±10.3% (p<0.001) in patients >65 years and to 3.8±7.1 (p<0.001) in patients ≤65 years. Mean LVEF showed a significant increase in both groups after ablation (43.4±10.4 vs. 51.5±8.2, p=0.005 for age >65 years and 40.8±13.2 vs. 49.5±11.8, p=0.003 for age ≤65 years). The improvement in LVEF was accompanied by a significant decrease in LVEDD (p=0.032 for age >65 years and p=0.047 for ≤65 years). Conclusion: Catheter ablation is effective for treatment of frequent VPCs in all age groups.

KW - Catheter ablation

KW - Electrocardiography

KW - Ventricular dysfunction, left

KW - Ventricular premature complexes / physiopathology

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