Abstract
Urethane and ketamine were tested for their ability to alter the caudally directed binding and scratching response elicited by the intrathecal (i.t.) injection of excitatory amino acids (EAAs) or substance P (SP). EAAs, such as N-methyl-D-aspartate (NMDA), kainate acid and quisqualic acid, but not SP, were inhibited by subanesthetic doses of urethane. In contrast, SP was more sensitive than NMDA to the inhibitory effect of (+)-ketamine. (-)-Ketamine produced much less inhibition of the SP-induced behaviors than the (+)isomer. These results have important implications regarding the use of urethane and ketamine as anesthetics for studies in which these excitatory compounds are potential mediators.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-177 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 184 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 2 1990 |
Bibliographical note
Funding Information:This research was supported by Umted States Pubhc Health Servace Grants NIDA00124, NIDA04090 and NIDA04190 The authors would hke to thank Drs Stephen R Slolhng and Chnstropher W Murray for their excellent e&tonal assistance in the preparation of ttus manuscript
Keywords
- Excitatory amino acids
- Ketamine
- Substance P
- Urethane