Abstract
Lateral ventricular injections of the 'nonspecific' opioid antagonist naloxone (100 ug) and the kappa-selective opioid antagonist nor-binaltorphimine (50 ug) elevated the electrical brain stimulation frequency threshold for eliciting feeding behavior. Mesopontine aqueductal injections of nor-binaltorphimine, on the other hand, lowered the feeding threshold while naloxone still elevated threshold. These findings suggest the existence of forebrain kappa receptors at which endogenous opioid activity results in a facilitation of feeding while kappa receptors in the brainstem seem to mediate an inhibitory effect.
Original language | English (US) |
---|---|
Pages (from-to) | 1787-1792 |
Number of pages | 6 |
Journal | Life Sciences |
Volume | 45 |
Issue number | 19 |
DOIs | |
State | Published - 1989 |