Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat

K. D. Carr, T. H. Bak, E. J. Simon, P. S. Portoghese

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Lateral ventricular injections of the 'nonspecific' opioid antagonist naloxone (100 ug) and the kappa-selective opioid antagonist nor-binaltorphimine (50 ug) elevated the electrical brain stimulation frequency threshold for eliciting feeding behavior. Mesopontine aqueductal injections of nor-binaltorphimine, on the other hand, lowered the feeding threshold while naloxone still elevated threshold. These findings suggest the existence of forebrain kappa receptors at which endogenous opioid activity results in a facilitation of feeding while kappa receptors in the brainstem seem to mediate an inhibitory effect.

Original languageEnglish (US)
Pages (from-to)1787-1792
Number of pages6
JournalLife Sciences
Volume45
Issue number19
DOIs
StatePublished - 1989

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