Effects of temperature on the anaesthetic potency of halothane, enflurane and ethanol in Daphnia magna (Cladocera: Crustacea)

J. Douglas McKenzie, Peter Calow, Julie Clyde, Angela Miles, Robert Dickinson, William R. Lieb, Nicholas P. Franks

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

1. The effects of temperature on the anaesthetic potencies of halothane, enflurane and ethanol have been studied in the water flea Daphnia magna. 2. In the absence of anaesthetics, decreasing temperature resulted in decreased activity by the daphnids. 3. Potencies in the gas phase decreased with increasing temperature for all of the anaesthetics, while aqueous potency decreased for halothane and enflurane but increased for ethanol. 4. Enthalpy calculations suggest that the observed potency changes for the inhalational anaesthetics cannot be accounted for in terms of changing solubility in lipid bilayers but most likely reflect more specific interactions with animal target sites.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume101
Issue number1
DOIs
StatePublished - Jan 1992
Externally publishedYes

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