Effects of T lymphocytes, interleukin-1, and interleukin-6 on renal fibrosis in canine end-stage renal disease

Ji Young Yhee, Chi Ho Yu, Jong Hyuk Kim, Jung Hyang Sur

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Canine end-stage renal disease (ESRD) is defined as the almost complete failure of renal function or irreversible destruction and is characterized by extensive glomerular sclerosis, tubular atrophy, interstitial inflammation, and fibrosis. Renal fibrosis is a common pathway leading to kidney failure. Infiltrating immunocytes in the end-stage kidney and several related factors are involved in renal fibrogenesis. A total of 18 renal tissue samples were obtained from canine patients with ESRD using biopsy and necropsy procedures. The extent of renal fibrosis was histopathologically examined by Masson trichrome staining. T-cell and B-cell localization and macrophage lineages were determined by immunohistochemical staining. Additionally, interleukin-1 (IL-1), IL-2, and IL-6 levels in the canine ESRD kidney were immunohistochemically evaluated and compared with expression patterns in the normal kidney. Significant fibrosis and infiltrating immunocytes consistent with lymphocytes were observed. Although the B-cell count was increased in the end-stage kidney, immunostaining patterns disclosed a marked increase in the number of CD 3+ cells. Furthermore, the remarkable increase in IL-1 and IL-6 levels suggests that T cells in the kidneys of dogs with ESRD spontaneously express these cytokines. In this study, the correlation between the degree of renal fibrosis and cytokines in canine ESRD was examined. The present study shows that T lymphocytes and IL-6 play important roles in renal fibrosis.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalJournal of Veterinary Diagnostic Investigation
Issue number5
StatePublished - Sep 1 2008
Externally publishedYes

Bibliographical note

Funding Information:
Thanks to Ms. R. H. Jang for excellent technical assistance. This paper was supported by Konkuk University in 2008. This report represents a thesis submitted by J.-Y. Yhee to fulfill the requirements for a PhD degree.


  • Canine
  • Fibrosis
  • Immunohistochemistry
  • Interleukin-1
  • Interleukin-6
  • Kidney failure
  • T lymphocytes


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