@inproceedings{884819844205413aa2e7b802c44c5168,
title = "Effects of supraphysiological temperatures on the plasma membrane of isolated skeletal muscle cells",
abstract = "We have investigated the effects of supraphysiological temperatures on the integrity and the permeability of the plasma membrane of isolated skeletal muscle cells. A thermal state and fluorescent microscopy system was used to expose the cells to well-defined temperatures between 37 and 70°C. The kinetics of thermal damage was assessed on real time using the fluorescent dye calcein-AM as a membrane integrity probe and the activation energy of the thermal damage process in the plasma membrane was 32.9 kcal/ mole. The F test statistically verified the superiority of the time dependent permeability fit indicating exposure to supraphysiological temperatures results in continuous hyperpermeabilization of the plasma membrane.",
author = "Padanilam, {J. T.} and Bischof, {J. C.} and Lee, {R. C.} and Cravalho, {E. G.} and Tompkins, {R. G.} and Yarmush, {M. L.} and M. Toner",
year = "1993",
month = dec,
day = "1",
language = "English (US)",
isbn = "079181047X",
series = "American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD",
publisher = "Publ by ASME",
pages = "69--72",
booktitle = "Advances in Bioheat and Mass Transfer",
note = "Proceedings of the 1993 ASME Winter Annual Meeting ; Conference date: 28-11-1993 Through 03-12-1993",
}