Effects of storage and wound healing on corneal biomechanics

J. C. Coleman, R. W. Beuerman, S. Kaufman, D. A. Rice

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Material testing techniques were used to characterize the mechanical properties of corneal tissue and to observe the effects of corneal storage and growth factors on these properties. Uniaxial stress-relaxation tests were performed on fresh and stored rabbit corneas. Fresh corneas recovered an average of 37.7% of first-pull stress while those stored in MK solution recovered an average of 76%. Stress-relaxation time constants were also found to be significantly different. Uniaxial tensile tests of fresh monkey corneas were performed to evaluate wound strengths of penetrating incisions treated with platelet derived growth factor (PDGF). Treated wounds demonstrated a greater failure strength than untreated wounds, indicating that corneal healing is enhanced in the presence of PDGF. Mechanical testing of corneal tissue is thus shown to be a useful technique for investigating changes in corneal structure.

Original languageEnglish (US)
Title of host publicationProceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages147-149
Number of pages3
ISBN (Electronic)0780309766, 9780780309760
DOIs
StatePublished - Jan 1 1993
Event12th Southern Biomedical Engineering Conference, SBEC 1993 - New Orleans, United States
Duration: Apr 2 1993Apr 4 1993

Publication series

NameProceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993

Conference

Conference12th Southern Biomedical Engineering Conference, SBEC 1993
CountryUnited States
CityNew Orleans
Period4/2/934/4/93

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Coleman, J. C., Beuerman, R. W., Kaufman, S., & Rice, D. A. (1993). Effects of storage and wound healing on corneal biomechanics. In Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993 (pp. 147-149). [247392] (Proceedings of the 12th Southern Biomedical Engineering Conference, SBEC 1993). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SBEC.1993.247392