Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm

James E. Mitchell, Blake A. Gosnell, James L. Roerig, Martina De Zwaan, Stephen A. Wonderlich, Ross D. Crosby, Melissa A. Burgard, Beth N. Wambach

Research output: Contribution to journalArticle

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Abstract

Objective: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating. Research Methods and Procedures: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout. Results: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine. Discussion: Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

Original languageEnglish (US)
Pages (from-to)599-602
Number of pages4
JournalObesity research
Volume11
Issue number5
DOIs
StatePublished - 2003

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    Mitchell, J. E., Gosnell, B. A., Roerig, J. L., De Zwaan, M., Wonderlich, S. A., Crosby, R. D., Burgard, M. A., & Wambach, B. N. (2003). Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm. Obesity research, 11(5), 599-602. https://doi.org/10.1038/oby.2003.85