Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm

James E. Mitchell; Blake A. Gosnell; James L. Roerig; Martina De Zwaan; Stephen A. Wonderlich; Ross D. Crosby; Melissa A. Burgard; Beth N. Wambach

doi:10.1038/oby.2003.85

Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm

James E. Mitchell, Blake A. Gosnell, James L. Roerig, Martina De Zwaan, Stephen A. Wonderlich, Ross D. Crosby, Melissa A. Burgard, Beth N. Wambach

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objective: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating. Research Methods and Procedures: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout. Results: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine. Discussion: Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

Original language	English (US)
Pages (from-to)	599-602
Number of pages	4
Journal	Obesity research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1038/oby.2003.85
State	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1038/oby.2003.85

Find It

Find It at U of M Libraries

Cite this

@article{9aa49a8c690d42d89970bfa0f172a4d9,

title = "Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm",

abstract = "Objective: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating. Research Methods and Procedures: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout. Results: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine. Discussion: Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.",

author = "Mitchell, {James E.} and Gosnell, {Blake A.} and Roerig, {James L.} and {De Zwaan}, Martina and Wonderlich, {Stephen A.} and Crosby, {Ross D.} and Burgard, {Melissa A.} and Wambach, {Beth N.}",

year = "2003",

doi = "10.1038/oby.2003.85",

language = "English (US)",

volume = "11",

pages = "599--602",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm

AU - Mitchell, James E.

AU - Gosnell, Blake A.

AU - Roerig, James L.

AU - De Zwaan, Martina

AU - Wonderlich, Stephen A.

AU - Crosby, Ross D.

AU - Burgard, Melissa A.

AU - Wambach, Beth N.

PY - 2003

Y1 - 2003

N2 - Objective: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating. Research Methods and Procedures: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout. Results: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine. Discussion: Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

AB - Objective: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating. Research Methods and Procedures: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout. Results: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine. Discussion: Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

UR - http://www.scopus.com/inward/record.url?scp=1542560767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542560767&partnerID=8YFLogxK

U2 - 10.1038/oby.2003.85

DO - 10.1038/oby.2003.85

M3 - Article

C2 - 12740447

AN - SCOPUS:1542560767

VL - 11

SP - 599

EP - 602

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -

Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this