Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs

Pei Ting Zhu, Jing Zhe Zhang, Xue Lin Zhang, Zuo Biao Yuan, Hong Ying Zhang, J. Gao

Research output: Contribution to journalArticlepeer-review

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OBJECTIVE: To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis. METHODS: Sixty female guinea pigs were randomized into 3 groups: group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltransferase (B-UGT) mRNA and cholesterol 7alpha-hydroxylase (CYP7A1) mRNA were observed. RESULTS: The proportions of stone-formed in groups I, II and III were 2/14, 9/12 and 4/14, respectively. There were significant differences among the three groups (P<0.05). The expressions of B-UGT and CYP7A1 mRNAs were higher in both group I and group III as compared with those in the group II (P<0.05). CONCLUSION: Shengqing Capsules can reduce the rate of stone-formation, which may be due to its interference of metabolism of bilirubin and cholesterol and up-regulation of the expressions of B-UGT and CYP7A1 mRNAs.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalZhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Issue number3
StatePublished - May 2005


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