Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults

25 y of follow up

Xuanxia Mao, Cheng Chen, Pengcheng Xun, Martha Daviglus, Lyn M Steffen, David R Jacobs Jr, Linda Van Horn, Stephen Sidney, Na Zhu, Ka He

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to examine the longitudinal association between seafood and intake of long-chain ω-3 polyunsaturated fatty acids (LCω-3 PUFA) and cognitive function and to explore the possible effect modifications owing to mercury (Hg) and selenium (Se) levels. Methods: Participants (N = 3231) from the CARDIA (Coronary Artery Risk Development in Young Adults) study underwent baseline examination and were reexamined in eight follow-up visits. Diet was assessed at baseline and in exam years 7 and 20. Toenail Hg and Se were measured at exam year 2. Cognitive function was measured at exam year 25 using three tests: Rey Auditory Verbal Learning Test (RAVLT), Digit Symbol Substitution Test (DSST), and the Stroop test. The general linear regression model was used to examine cumulative average intakes of LCω-3 PUFA and seafood in relation to the cognitive test scores; and to explore the possible effect modifications caused by Hg and Se. Results: LCω-3 PUFA intake was significantly associated with better performance in the DSST test (quintile 5 versus quintile 1; mean difference = 1.74; 95% confidence interval, 0.19–3.29; P trend , 0.048]), but not in the RAVLT and Stroop tests. Similar results were observed for intakes of eicosapentaenoic acid, docosahexaenoic acid, and non-fried seafood. The observed associations were more pronounced in participants with body mass index ≥25 kg/m 2 , but not significantly modified by toenail Hg or Se. Conclusion: This longitudinal study supported the hypothesis that LCω-3 PUFA or non-fried seafood intake is associated with better cognitive performance in psychomotor speed among US adults, especially those who are overweight or obese.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalNutrition
Volume61
DOIs
StatePublished - May 1 2019

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Seafood
Selenium
Nails
Mercury
Unsaturated Fatty Acids
Cognition
Stroop Test
Verbal Learning
Linear Models
Psychomotor Performance
Eicosapentaenoic Acid
Docosahexaenoic Acids
Longitudinal Studies
Young Adult
Coronary Vessels
Body Mass Index
Confidence Intervals
Diet

Keywords

  • Cognitive function
  • Hg
  • LCω-3 PUFA
  • Se
  • Seafood consumption

PubMed: MeSH publication types

  • Journal Article

Cite this

Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults : 25 y of follow up. / Mao, Xuanxia; Chen, Cheng; Xun, Pengcheng; Daviglus, Martha; Steffen, Lyn M; Jacobs Jr, David R; Van Horn, Linda; Sidney, Stephen; Zhu, Na; He, Ka.

In: Nutrition, Vol. 61, 01.05.2019, p. 77-83.

Research output: Contribution to journalArticle

Mao, Xuanxia ; Chen, Cheng ; Xun, Pengcheng ; Daviglus, Martha ; Steffen, Lyn M ; Jacobs Jr, David R ; Van Horn, Linda ; Sidney, Stephen ; Zhu, Na ; He, Ka. / Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults : 25 y of follow up. In: Nutrition. 2019 ; Vol. 61. pp. 77-83.
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abstract = "Objectives: The aim of this study was to examine the longitudinal association between seafood and intake of long-chain ω-3 polyunsaturated fatty acids (LCω-3 PUFA) and cognitive function and to explore the possible effect modifications owing to mercury (Hg) and selenium (Se) levels. Methods: Participants (N = 3231) from the CARDIA (Coronary Artery Risk Development in Young Adults) study underwent baseline examination and were reexamined in eight follow-up visits. Diet was assessed at baseline and in exam years 7 and 20. Toenail Hg and Se were measured at exam year 2. Cognitive function was measured at exam year 25 using three tests: Rey Auditory Verbal Learning Test (RAVLT), Digit Symbol Substitution Test (DSST), and the Stroop test. The general linear regression model was used to examine cumulative average intakes of LCω-3 PUFA and seafood in relation to the cognitive test scores; and to explore the possible effect modifications caused by Hg and Se. Results: LCω-3 PUFA intake was significantly associated with better performance in the DSST test (quintile 5 versus quintile 1; mean difference = 1.74; 95{\%} confidence interval, 0.19–3.29; P trend , 0.048]), but not in the RAVLT and Stroop tests. Similar results were observed for intakes of eicosapentaenoic acid, docosahexaenoic acid, and non-fried seafood. The observed associations were more pronounced in participants with body mass index ≥25 kg/m 2 , but not significantly modified by toenail Hg or Se. Conclusion: This longitudinal study supported the hypothesis that LCω-3 PUFA or non-fried seafood intake is associated with better cognitive performance in psychomotor speed among US adults, especially those who are overweight or obese.",
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AU - Mao, Xuanxia

AU - Chen, Cheng

AU - Xun, Pengcheng

AU - Daviglus, Martha

AU - Steffen, Lyn M

AU - Jacobs Jr, David R

AU - Van Horn, Linda

AU - Sidney, Stephen

AU - Zhu, Na

AU - He, Ka

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