The influence of an infusion of PGB1 upon circulating levels of insulin, glucose and free fatty acids in anesthetized dogs both in the basal state and following stimulation with intravenous glucose or norepinephrine was not significantly different from saline-treated controls. Since no increment in immunoreactive PGE was found in thoracic aorta plasma during PGB1 infusion, it is unlikely that the observed trends in the insulin, glucose and free fatty acid data during PGB1 infusion were due to simultaneous endogenous PGE formation.
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ACRN(WLEDGEMENTS: The technicala ssistanceo f Mr. Howard Beiter, Miss Martha Rimura and Mrs. Julianne Carlin and the generous supply of prostaglandinf rom Dr. John Pike (Upjohn Co.) are gratefully acknowledged. This work was supportedb y the Veterans Administration Research and Education program, and NIH Project Grants AM-06670 and AH-12829.